Tfap2b mutation in mice results in patent ductus arteriosus and renal malformation

Using the c.435_438delCCGG homozygous mice, we verified the nature of the c.435_438delCCGG mutation and established a new and useful animal model to explore the function of Tfap2b and the mechanisms of PDA and renal formation. These findings may be useful for the development of therapies for those rare disorder.