Physiologic levels of resistin induce a shift from proliferation to apoptosis in macrophage and VSMC co-culture

Resistin promotes a shift from proliferation to apoptosis in vascular smooth muscle cells and macrophage co-culture systems with cellular composition similar to that found in vulnerable regions of plaques. Protein kinase C epsilon mediates the effects of resistin, suggesting that protein kinase C epsilon may represent a therapeutic strategy in resistin-associated atherosclerotic complications.