کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8837697 | 1612885 | 2018 | 31 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Impaired spatial processing in a mouse model of fragile X syndrome
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب رفتاری
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چکیده انگلیسی
Fragile X syndrome (FXS) is the most common form of inherited intellectual impairment. The Fmr1â/y mouse model has been previously shown to have deficits in context discrimination tasks but not in the elevated plus-maze. To further characterize this FXS mouse model and determine whether hippocampal-mediated behaviours are affected in these mice, dentate gyrus (DG)-dependent spatial processing and Cornu ammonis 1 (CA1)-dependent temporal order discrimination tasks were evaluated. In agreement with previous findings of long-term potentiation deficits in the DG of this transgenic model of FXS, the results reported here demonstrate that Fmr1â/y mice perform poorly in the DG-dependent metric change spatial processing task. However, Fmr1â/y mice did not present deficits in the CA1-dependent temporal order discrimination task, and were able to remember the order in which objects were presented to them to the same extent as their wild-type littermate controls. These data suggest that the previously reported subregional-specific differences in hippocampal synaptic plasticity observed in the Fmr1â/y mouse model may manifest as selective behavioural deficits in hippocampal-dependent tasks.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Behavioural Brain Research - Volume 350, 17 September 2018, Pages 72-79
Journal: Behavioural Brain Research - Volume 350, 17 September 2018, Pages 72-79
نویسندگان
Mohamed Ghilan, Luis E.B. Bettio, Athena Noonan, Patricia S. Brocardo, Joana Gil-Mohapel, Brian R. Christie,