کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8837796 | 1612888 | 2018 | 32 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Sleep-related brain atrophy and disrupted functional connectivity in older adults
ترجمه فارسی عنوان
آتروفی مغزی مرتبط با خواب و اختلال عملکردی در افراد مسن تر
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کلمات کلیدی
سالخورده، خواب حجم مغز، اتصال به عملکرد
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب رفتاری
چکیده انگلیسی
Aging associates with sleep dysfunction as well as brain alterations. However, the association between age-related brain alterations and their subjective sleep changes is less understood. To address this issue, we recorded T1 weighted structural and resting-state functional magnetic resonance imaging from both young (nâ¯=â¯62) and older adults (nâ¯=â¯108). In addition, all participants completed a battery of psychometric tests, including the Pittsburg Sleep Quality Index. We found that the age-related atrophy of cerebral gray matter, hippocampal and thalamic volume were associated with subjective sleep decline, and the atrophy of cerebral gray matter mediated the age effect on sleep. In addition, older adults exhibited decreased functional connectivity within the medial temporal lobe subsystem than their young counterparts. Moreover, there is a significant positive association between sleep and functional connectivity in young but not in older adults. In light of our findings, we suggest a neuropathological model in which age-related brain alterations may partially explain the well-documented declines in sleep with aging.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Behavioural Brain Research - Volume 347, 16 July 2018, Pages 292-299
Journal: Behavioural Brain Research - Volume 347, 16 July 2018, Pages 292-299
نویسندگان
Yun-Rui Liu, Dong-Qiong Fan, Wen-Jun Gui, Zhi-Liang Long, Xu Lei, Jing Yu,