کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8838321 | 1613094 | 2018 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Children with ASD show links between aberrant sound processing, social symptoms, and atypical auditory interhemispheric and thalamocortical functional connectivity
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کلمات کلیدی
Corpus callosumStgSRSADI-RFunctional connectivity - اتصال عملکردی autism spectrum disorders - اختلالات طیف اوتیسمAutism spectrum disorder - اختلالات طیف اوتیسم گروهیMRI - امآرآی یا تصویرسازی تشدید مغناطیسیAutism Diagnostic Observation Schedule - برنامه ریزی تشخیص اوتیسمtypically developing - به طور معمول در حال توسعه استintelligence quotient - بهره هوشیThalamus - تالاموسMagnetic resonance imaging - تصویربرداری رزونانس مغناطیسیfMRI - تصویرسازی تشدید مغناطیسی کارکردیsuperior temporal gyrus - جورج جادویی عالیAuditory - شنواییHeschl’s gyrus - طوطی هشلSensory profile - مشخصات حسیSocial Responsiveness Scale - مقیاس پاسخگویی اجتماعیASD - نقص سپتوم یا دیوارهی دهلیزیADOS - نوجوانان
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب رفتاری
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چکیده انگلیسی
Autism spectrum disorder (ASD) is a complex and prevalent neurodevelopmental disorder characterized by social and communicative deficits, as well as repetitive behaviors and atypical sensitivity to sensory stimulation. Alterations in network connectivity are widely recognized, but their interplay with social and sensory symptoms remains largely unclear. Here, functional magnetic resonance imaging and diagnostic and behavioral assessments were used in a cohort of children and adolescents with ASD (n = 40) and matched typically developing (TD, n = 38) controls to examine the relation between auditory processing, interhemispheric and thalamocortical network connectivity, and social-behavioral symptom severity. We found that atypical processing of sounds was related to social, cognitive, and communicative impairments. Additionally, severity of sensory processing deficits and lower verbal IQ were related to reduced interhemispheric connectivity of auditory cortices in ASD. Increased connectivity between the thalamus and auditory cortex in ASD, however, was associated with reduced cognitive and behavioral symptomatology, suggesting that thalamocortical overconnectivity might reflect a compensatory mechanism in ASD. These findings provide novel evidence for links between auditory sensory deficits and impairments in social interaction and communication.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Developmental Cognitive Neuroscience - Volume 29, January 2018, Pages 117-126
Journal: Developmental Cognitive Neuroscience - Volume 29, January 2018, Pages 117-126
نویسندگان
Annika C. Linke, R. Joanne Jao Keehn, Ellyn B. Pueschel, Inna Fishman, Ralph-Axel Müller,