کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8838855 | 1613217 | 2018 | 12 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Neonatal whisker trimming in WAG/Rij rat pups causes developmental delay, encourages maternal care and affects exploratory activity in adulthood
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب سلولی و مولکولی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Neonatal whisker trimming in WAG/Rij rat pups causes developmental delay, encourages maternal care and affects exploratory activity in adulthood Neonatal whisker trimming in WAG/Rij rat pups causes developmental delay, encourages maternal care and affects exploratory activity in adulthood](/preview/png/8838855.png)
چکیده انگلیسی
WAG/Rij rats are genetically predisposed to absence epilepsy. Maternal behavior in WAG/Rij female rats is known to differ from that in non-epileptic females. We hypothesize that (1) mother's behavior may be changed as response to changes in pup's conditions; (2) sensory deprivation at the neonatal age affect learning and behavior in adulthood. All whiskers in WAG/Rij rat pups were trimmed daily during PN1-PN8. Maternal behavior was examined during the same period. It was found that in the control group, WAG/Rij females often demonstrated abnormally long (>1â¯min) repetitive purposeless stereotypical actions that were roughly classified as compulsive-like behavior. Mothers of the trimmed pups showed less compulsive-like behavior and more intensively interacted with pups and built better nests. Rat pups in the trimmed group had lower body weight on PN7-PN19 as compared to the control. In the trimmed group, maturation of motor skills and early behavioral patterns (i.e. walking, grooming, vertical activity, motor functions of forelimbs) showed 1-2â¯days delay in comparison to the control. At the age of 2-2.5 months, the locomotor activity in the trimmed rats differed from the control, but the level of anxiety was the same (the open field and the elevated plus maze). At the age of 6 months, the trimmed and control rats showed no differences in conditioned avoidance learning test, therefore, neonatal whisker trimming did not influence fear-based learning abilities in adulthood. It is hypothesized that an enhanced maternal care is capable to modulate development of brain functions in sensory deprived progeny.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Brain Research Bulletin - Volume 140, June 2018, Pages 120-131
Journal: Brain Research Bulletin - Volume 140, June 2018, Pages 120-131
نویسندگان
Kirill Smirnov, Daria Tsvetaeva, Evgenia Sitnikova,