کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8839030 | 1613220 | 2018 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Acetylshikonin from Zicao attenuates cognitive impairment and hippocampus senescence in d-galactose-induced aging mouse model via upregulating the expression of SIRT1
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موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب سلولی و مولکولی
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چکیده انگلیسی
Zicao acts as a pleiotropic medicine in various diseases due to its particular pharmacological properties, including anti-inflammatory, anti-tumor, anti-oxidative, and wound healing effects. However, few studies have focused on the function in neurodegenerative diseases of Zicao. In this study, we investigated the neuroprotective effect of Acetylshikonin (AS) from Zicao on the hippocampus of the d-galactose (d-gal)-induced sub-acute aging mouse model of Alzheimer's disease (AD). The aging model was established in male Kunming mice by subcutaneous injection of d-gal (150â¯mg/kg/d) for 60â¯days, and the mice were given AS (270, 540 and 1080â¯mg/kg/d) or distilled water intragastrically for 30â¯days after 30â¯days of d-gal injection. The behavioral results test by Morris Water Maze (MWM) revealed that chronic AS treatment alleviated d-gal-induced learning and memory deficits compared with the d-gal-treated mice. In addition, AS also ameliorated the oxidative stress and neuroinflammation induced by d-gal through decreasing the level of interleukin-1β (IL-1β), tumor necrosis factor α (TNF-α), malondialdehyde (MDA) and enhancing the activity of the antioxidant enzymes superoxide dismutase (SOD). Moreover, western blot results showed that AS can up-regulate the expression of Sirtuin 1 (SIRT1) and inhibit d-gal-induced activation of p53/p21 signaling pathway in the hippocampus of mice. These results suggest that AS can execute the prevention and treatment of d-gal-induced brain aging by SIRT1/P53/P21 pathway.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Brain Research Bulletin - Volume 137, March 2018, Pages 311-318
Journal: Brain Research Bulletin - Volume 137, March 2018, Pages 311-318
نویسندگان
Qisen Li, Jiacheng Zeng, Meiling Su, Yu He, Banghao Zhu,