کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8839075 | 1613222 | 2017 | 47 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
ATP released from astrocytes modulates action potential threshold and spontaneous excitatory postsynaptic currents in the neonatal rat prefrontal cortex
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کلمات کلیدی
BzATPSubplate neuronsubplate zoneBBGBrilliant Blue GPPADSsEPSCLPSTTXMAMSPNPPISPZPFCATP - آدنوزین تری فسفات یا ATPAstrocyte - آستروسیتSchizophrenia - اسکیزوفرنی یا شیزوفرنیtetrodotoxin - تترو دوتوکسین Suramin - سارامینprefrontal cortex - قشر prefrontallipopolysaccharide - لیپوپلی ساکاریدmethylazoxymethanol - متیلازوکمتانولpre-pulse inhibition - مهار پیش از پالسP2X7 receptor - گیرنده P2X7
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب سلولی و مولکولی
پیش نمایش صفحه اول مقاله

چکیده انگلیسی
Exogenous ATP increased the frequency and amplitude of spontaneous excitatory postsynaptic currents (sEPSCs) at micromolar concentrations. Further, ATP released by astrocytes activated by the PAR-1 agonist, TFLLR-NH2, also increased the amplitude and frequency of sEPSCs in subplate neurons. The electrophysiological properties of subplate neurons recorded from prefrontal cortical (PFC) slices from neonatal rats were also disrupted in a maternal immune activation rat model of schizophrenia, with a suramin-sensitive increase in frequency and amplitude of sEPSCs. An alternative neurodevelopmental rat model of schizophrenia, MAM-E17, which did not rely on maternal immune activation, however, showed no change in subplate neuron activity. Both models were validated with behavioral assays, showing schizophrenia-like endophenotypes in young adulthood. The purinergic modulation of subplate neuron activity offers a potential explanatory link between maternal immune activation and disruptions in cortical development that lead to the emergence of neuropsychiatric disorders.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Brain Research Bulletin - Volume 135, October 2017, Pages 129-142
Journal: Brain Research Bulletin - Volume 135, October 2017, Pages 129-142
نویسندگان
Edward Beamer, Gergely Kovács, Beata Sperlágh,