کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8839711 | 1613750 | 2018 | 48 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
The angiotensin II type I receptor antagonist losartan retards amygdala kindling-induced epileptogenesis
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کلمات کلیدی
i.p.TGF-βAT1i.c.v.intracerebroventricularECMADTTGF-β signaling - TGF-β سیگنالینگAmygdala kindling - آمیگدال لیفتینگangiotensin II type 1 receptor - آنژیوتانسین II نوع 1 گیرندهgamma-aminobutyric acid - اسید گاما آمینو بوتیریکElectroencephalography - الکتروانسافالوگرافیafterdischarge threshold - بعد از تخلیه آستانهtransforming growth factor-β - تبدیل فاکتور رشد βanalysis of variance - تحلیل واریانسANOVA - تحلیل واریانس Analysis of varianceintraperitoneal - داخل صفاقیBBB - سد خونی مغزیlosartan - لوزارتانExtracellular matrix - ماتریکس خارج سلولیBlood-brain barrier - مانع خون مغزیEEG - نوار مغزیParvalbumin - پاروالبومینGABA - گابا
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: The angiotensin II type I receptor antagonist losartan retards amygdala kindling-induced epileptogenesis The angiotensin II type I receptor antagonist losartan retards amygdala kindling-induced epileptogenesis](/preview/png/8839711.png)
چکیده انگلیسی
Blood-brain barrier (BBB) breakdown and the subsequent exposure of the cerebral cortex to serum albumin are known to activate transforming growth factor β (TGF-β) signaling in astrocytes and to play key roles in epileptogenesis after brain injury. It was recently reported that the angiotensin II type I receptor antagonist losartan suppresses activation of TGF-β signaling and prevents epileptogenesis in a rat vascular injury model. Here, we investigated the effects of losartan on epileptogenesis following amygdala kindling in rats. Systemic or intracerebroventricular (i.c.v.) administration of losartan significantly delayed the development of severe behavioral seizures and stimulus-induced seizures on EEG (afterdischarge) in the early stage of amygdala kindling, as assessed by electroencephalography. Losartan also significantly increased the number of stimulations required to reach the fully kindled state. However, losartan had no effects on the threshold for afterdischarge induction, the afterdischarge duration, or seizure severity in fully kindled rats. Evaluation of BBB permeability by Evans blue staining did not indicate BBB breakdown (extravasation of serum albumin) in any region of the brain in the fully kindled animals. Thus, losartan may be useful in preventing epileptogenesis, even in post brain-insult epilepsy, in the absence of BBB breakdown.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Brain Research - Volume 1694, 1 September 2018, Pages 121-128
Journal: Brain Research - Volume 1694, 1 September 2018, Pages 121-128
نویسندگان
Toshiki Nozaki, Hiroyuki Ura, Ichiro Takumi, Shiro Kobayashi, Eiichi Maru, Akio Morita,