کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8839875 1613762 2018 12 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
No evidence for systematic white matter correlates of dyslexia: An Activation Likelihood Estimation meta-analysis
ترجمه فارسی عنوان
هیچ مدرکی مبنی بر وجود ماده سفید سیستماتیک در رابطه با نارساخوانی وجود ندارد: یک متاآنالیز ارزیابی احتمال فعال بودن
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب (عمومی)
چکیده انگلیسی
Dyslexia is a prevalent neurodevelopmental disorder, characterized by reading and spelling difficulties. Beyond the behavioral and functional correlates of this condition, a growing number of studies have explored structural differences between individuals with dyslexia and typically developing individuals. To date, findings remain disparate - some studies suggest differences in fractional anisotropy (FA), an indirect measure of white matter integrity, whereas others do not identify significant disparities. Here, we synthesized the existing literature on this topic by conducting a meta-analysis of Diffusion Tensor Imaging (DTI) studies investigating white matter correlates of dyslexia via voxel-based analyses (VBA) of FA. Our results showed no reliable clusters underlying differences between dyslexics and typical individuals, after correcting for multiple comparisons (false discovery rate correction). Because group comparisons might be too coarse to yield subtle differences, we further explored differences in FA as a function of reading ability, measured on a continuous scale. Consistent with our initial findings, reading ability was not associated with reliable differences in white matter integrity. These findings nuance the current view of profound, structural differences underlying reading ability and its associated disorders, and suggest that their neural correlates might be more subtle than previously thought.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Brain Research - Volume 1683, 15 March 2018, Pages 36-47
نویسندگان
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