کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8840796 | 1614697 | 2018 | 55 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Phase-specific Surround suppression in Mouse Primary Visual Cortex Correlates with Figure Detection Behavior Based on Phase Discontinuity
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کلمات کلیدی
ROCaCSF2AFCCSDAAVLFPPSSILGNSOM - WHOOptogenetics - اپتوژنتیکcurrent source density - تراکم منبع فعلیRodent - جوندگانTwo-alternative forced choice - دو گزینه انتخاب مجازVisual behavior - رفتار بصریreceptive field - زمینه پذیرشSuperior colliculus - ستارگان برترSomatostatin - سوماتواستاتینFigure-ground - شکل زمینSpatial frequency - فرکانس فضاییprimary visual cortex - قشر بصری اولیهsecondary visual cortex - قشر متوسط ثانویهartificial cerebrospinal fluid - مایع مغزی نخاعی مصنوعیContextual modulation - مدولاسیون متنیlateral geniculate nucleus - هسته ژنیکول جانبی جانبیAdeno-associated virus - ویروس Adeno مرتبط استParvalbumin - پاروالبومینlocal field potential - پتانسیل منطقه ایreceiver operating characteristic - گیرنده عامل عامل
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
In the primary visual cortex (V1), neuronal responses to stimuli within the receptive field (RF) are modulated by stimuli in the RF surround. A common effect of surround modulation is surround suppression, which is dependent on the feature difference between stimuli within and surround the RF and is suggested to be involved in the perceptual phenomenon of figure-ground segregation. In this study, we examined the relationship between feature-specific surround suppression of V1 neurons and figure detection behavior based on figure-ground feature difference. We trained freely moving mice to perform a figure detection task using figure and ground gratings that differed in spatial phase. The performance of figure detection increased with the figure-ground phase difference, and was modulated by stimulus contrast. Electrophysiological recordings from V1 in head-fixed mice showed that the increase in phase difference between stimuli within and surround the RF caused a reduction in surround suppression, which was associated with an increase in V1 neural discrimination between stimuli with and without RF-surround phase difference. Consistent with the behavioral performance, the sensitivity of V1 neurons to RF-surround phase difference could be influenced by stimulus contrast. Furthermore, inhibiting V1 by optogenetically activating either parvalbumin (PV)- or somatostatin (SOM)-expressing inhibitory neurons both decreased the behavioral performance of figure detection. Thus, the phase-specific surround suppression in V1 represents a neural correlate of figure detection behavior based on figure-ground phase discontinuity.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience - Volume 379, 21 May 2018, Pages 359-374
Journal: Neuroscience - Volume 379, 21 May 2018, Pages 359-374
نویسندگان
Fengling Li, Weiqian Jiang, Tian-Yi Wang, Taorong Xie, Haishan Yao,