کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8840862 | 1614700 | 2018 | 45 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Cell Type-specific Intrinsic Perithreshold Oscillations in Hippocampal GABAergic Interneurons
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
APVA-type K+ currentCGP55845PVBCSR95531NBQXINaPCREnNOSN-methyl-d-aspartateNMDATTXCCKHEPESSCANPYAMPAaCSF2-amino-5-phosphonopentanoic acid - 2-آمینو-5-فسفونوپنتانوئیک اسید4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid - 4- (2-hydroxyethyl) -1-piperazineethanesulfonic acidα-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid - اسید α-آمینو 3-هیدروکسی-5-متیل-4-ایزوکسول پپونیکfast-spiking interneurons - اینترنورونهای سریع اسپیکینگtetrodotoxin - تترو دوتوکسین Delayed rectifier current - جریان پایه گذارResonance - رزونانسPersistent sodium current - سدیم مداوم سدیمneuronal nitric oxide synthase - سنتاز اکسید نیتریک عصبیartificial cerebrospinal fluid - مایع مغزی نخاعی مصنوعیNetwork oscillation - نوسان شبکهaction potential - پتانسیل عمل Cre recombinase - کرم recombinasecholecystokinin - کولهسیستوکینینGABA - گاباNeuropeptide Y - یوروپروتئین Y
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
The hippocampus plays a critical role in learning, memory, and spatial processing through coordinated network activity including theta and gamma oscillations. Recent evidence suggests that hippocampal subregions (e.g., CA1) can generate these oscillations at the network level, at least in part, through GABAergic interneurons. However, it is unclear whether specific GABAergic interneurons generate intrinsic theta and/or gamma oscillations at the single-cell level. Since major types of CA1 interneurons (i.e., parvalbumin-positive basket cells (PVBCs), cannabinoid type 1 receptor-positive basket cells (CB1BCs), Schaffer collateral-associated cells (SCAs), neurogliaform cells and ivy cells) are thought to play key roles in network theta and gamma oscillations in the hippocampus, we tested the hypothesis that these cells generate intrinsic perithreshold oscillations at the single-cell level. We performed whole-cell patch-clamp recordings from GABAergic interneurons in the CA1 region of the mouse hippocampus in the presence of synaptic blockers to identify intrinsic perithreshold membrane potential oscillations. The majority of PVBCs (83%), but not the other interneuron subtypes, produced intrinsic perithreshold gamma oscillations if the membrane potential remained above â45â¯mV. In contrast, CB1BCs, SCAs, neurogliaform cells, ivy cells, and the remaining PVBCs (17%) produced intrinsic theta, but not gamma, oscillations. These oscillations were prevented by blockers of persistent sodium current. These data demonstrate that the major types of hippocampal interneurons produce distinct frequency bands of intrinsic perithreshold membrane oscillations.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience - Volume 376, 15 April 2018, Pages 80-93
Journal: Neuroscience - Volume 376, 15 April 2018, Pages 80-93
نویسندگان
Young-Jin Kang, Hannah Elisabeth Smashey Lewis, Mason William Young, Gubbi Govindaiah, Lazar John Jr., Edgar Garcia-Rill, Sang-Hun Lee,