کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8840991 | 1614704 | 2018 | 48 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
A High-fat, High-sugar 'Western' Diet Alters Dorsal Striatal Glutamate, Opioid, and Dopamine Transmission in Mice
ترجمه فارسی عنوان
یک رژیم غذایی با چربی بالا و قند "غربی" باعث انتقال پروتئین گلوتامات پشتی، اپوئید و دوپامین در موش می شود
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کلمات کلیدی
MOPrsEPSCsHEPESMSNsEGTAGTTFSCVaCSF4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid - 4- (2-hydroxyethyl) -1-piperazineethanesulfonic acidEPSC - EPSCoRinsulin tolerance test - آزمون تحمل انسولینethylene glycol-bis(β-aminoethyl ether)-N,N,N′,N′-tetraacetic acid - اتیلن گلیکول بیس (β-آمینویل اتر) -N، N، N '، N'-tetraacetic اسیدdorsal striatum - استریاتوم پشتیElectrophysiology - الکتروفیزیولوژیITT - اینجاglucose tolerance test - تست تحمل گلوکزexcitatory postsynaptic current - جریان پستیینپتیک تحریک کنندهDopamine - دوپامینstandard diet - رژیم استانداردWestern diet - رژیم غربیartificial cerebrospinal fluid - مایع مغزی نخاعی مصنوعیObesity - مرض چاقیMice - موشmedium spiny neurons - نورونهای کروی متوسطFast-scan cyclic voltammetry - ولتاژ سنجی چرخه سرعت اسکنglutamate - گلوتاماتmu-opioid receptor - گیرنده ی مئو-اپوئیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
چکیده انگلیسی
Understanding neuroadaptations involved in obesity is critical for developing new approaches to treatment. Diet-induced neuroadaptations within the dorsal striatum have the capacity to drive excessive food seeking and consumption. Five-week-old C57BL/6J mice consumed a high-fat, high-sugar 'western diet' (WD) or a control 'standard diet' (SD) for 16â¯weeks. Weight gain, glucose tolerance, and insulin tolerance were measured to confirm an obese-like state. Following these 16â¯weeks, electrophysiological recordings were made from medium spiny neurons (MSNs) in the medial (DMS) and lateral (DLS) portions of dorsal striatum to evaluate diet effects on neuronal excitability and synaptic plasticity. In addition, fast-scan cyclic voltammetry evaluated dopamine transmission in these areas. WD mice gained significantly more weight and consumed more calories than SD mice and demonstrated impaired glucose tolerance. Electrophysiology data revealed that MSNs from WD mice demonstrated increased AMPA-to-NMDA receptor current ratio and prolonged spontaneous glutamate-mediated currents, specifically in the DLS. Evoked dopamine release was also significantly greater and reuptake slower in both subregions of WD striatum. Finally, dorsal striatal MSNs from WD mice were significantly less likely to demonstrate mu-opioid receptor-mediated synaptic plasticity. Neuronal excitability and GABAergic transmission were unaffected by diet in either striatal subregion. Our results demonstrate that a high-fat, high-sugar diet alters facets of glutamate, dopamine, and opioid signaling within the dorsal striatum, with some subregion specificity. These alterations within a brain area known to play a role in food motivation/consumption and habitual behavior are highly relevant for the clinical condition of obesity and its treatment.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience - Volume 372, 21 February 2018, Pages 1-15
Journal: Neuroscience - Volume 372, 21 February 2018, Pages 1-15
نویسندگان
Brandon M. Fritz, Braulio Muñoz, Fuqin Yin, Casey Bauchle, Brady K. Atwood,