کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8841042 | 1614705 | 2018 | 12 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
α1b-Adrenergic Receptor Localization and Relationship to the D1-Dopamine Receptor in the Rat Nucleus Accumbens
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کلمات کلیدی
ABCAlpha1-adrenergic receptorPMBD1RVTAGPCRintTBSNACNGSDABPBSPFCIgG3,3-diaminobenzidine tetrahydrochloride - 3،3-دیامینبنزیدین تتراهیدرکلرایدBSA - BSAbovine serum albumin - آلبومین سرم گاوattention deficit hyperactivity disorder - اختلال کمتوجّهی _ بیشفعالیimmunoglobulin G - ایمونوگلوبولین Gphosphate buffer - بافر فسفاتADHD - بیشفعالیanalysis of variance - تحلیل واریانسANOVA - تحلیل واریانس Analysis of varianceTris-buffered saline - تریس بافر شورIntracellular - داخل سلولیRoom temperature - دمای اتاقDopamine - دوپامینnormal goat serum - سرم طبیعی بزprefrontal cortex - قشر prefrontallocus coeruleus - لوکوس سیرولئوسPhosphate-buffered saline - محلول نمک فسفات با خاصیت بافریventral tegmental area - ناحیه تگمنتوم شکمیnorepinephrine - نوراپی نفرینNucleus accumbens - هسته accumbensG protein-coupled receptor - گیرندههای جفتشونده با پروتئین جی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
The α1-adrenergic receptors (α1ARs) have been implicated in numerous actions of the brain, including attention and wakefulness. Additionally, they have been identified as contributing to disorders of the brain, such as drug addiction, and recent work has shown a role of these receptors in relapse to psychostimulants. While some functionality is known, the actual subcellular localization of the subtypes of the α1ARs remains to be elucidated. Further, their anatomical relationship to receptors for other neurotransmitters, such as dopamine (DA), remains unclear. Therefore, using immunohistochemistry and electron microscopy techniques, this study describes the subcellular localization of the α1b-adrenergic receptor (α1bAR), the subtype most tied to relapse behaviors, as well as its relationship to the D1-dopamine receptor (D1R) in both the shell and core of the rat nucleus accumbens (NAc). Overall, α1bARs were found in unmyelinated axons and axon terminals with some labeling in dendrites. In accordance with other studies of the striatum, the D1R was found mainly in dendrites and spines; therefore, colocalization of the D1R with the α1bAR was rare postsynaptically. However, in the NAc shell, when the receptors were co-expressed in the same neuronal elements there was a trend for both receptors to be found on the plasma membrane, as opposed to the intracellular compartment. This study provides valuable anatomical information about the α1bAR and its relationship to the D1R and the regulation of DA and norepinephrine (NE) neurotransmission in the brain which have been examined previously.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience - Volume 371, 10 February 2018, Pages 126-137
Journal: Neuroscience - Volume 371, 10 February 2018, Pages 126-137
نویسندگان
Darlene A. Mitrano, Kelsey Jackson, Samantha Finley, Allison Seeley,