کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8841066 1614705 2018 26 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Monaural-driven Functional Changes within and Beyond the Auditory Cortical Network: Evidence from Long-term Unilateral Hearing Impairment
ترجمه فارسی عنوان
تغییرات عملکردی درون و بیرون شبکه کوریتی گوش شنونده: شواهدی از اختلال شنوایی یک طرفه درازمدت
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب (عمومی)
چکیده انگلیسی
Long-term unilateral hearing impairment (UHI) results in changes in hearing and psychoacoustic performance that are likely related to cortical reorganization. However, the underlying functional changes in the brain are not yet fully understood. Here, we studied alterations in inter- and intra-hemispheric resting-state functional connectivity (RSFC) in 38 patients with long-term UHI caused by acoustic neuroma. Resting-state fMRI data from 17 patients with left-sided hearing impairment (LHI), 21 patients with right-sided hearing impairment (RHI) and 21 healthy controls (HCs) were collected. We applied voxel-mirrored homotopic connectivity analysis to investigate the interhemispheric interactions. To study alterations in between-network interactions, we used four cytoarchitectonically identified subregions in the auditory cortex as “seeds” for whole-brain RSFC analysis. We found that long-term imbalanced auditory input to the brain resulted in (1) enhanced interhemispheric RSFC between the contralateral and ipsilateral auditory networks and (2) differential patterns of altered RSFCs with other sensory (visual and somatomotor) and higher-order (default mode and ventral attention) networks among the four auditory cortical subregions. These altered RSFCs within and beyond the auditory network were dependent on the side of hearing impairment. The results were reproducible when the analysis was restricted to patients with severe-to-profound UHI and patients with hearing-impairment durations greater than 24 months. Together, we demonstrated that long-term UHI drove cortical functional changes within and beyond the auditory network, providing empirical evidence for the association between brain changes and hearing disorders.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience - Volume 371, 10 February 2018, Pages 296-308
نویسندگان
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