کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8841093 | 1614705 | 2018 | 25 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Micro-coil-induced Inhomogeneous Electric Field Produces sound-driven-like Neural Responses in Microcircuits of the Mouse Auditory Cortex In Vivo
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کلمات کلیدی
CSDTMSICMSElectrocochleographyPSTHLFPMEAAAFTTXECoGaCSFMultielectrode array - آرایه مولتی الکترودهایγ-aminobutyric acid - اسید γ-آمینوبوتیریکElectroencephalography - الکتروانسافالوگرافیstandard deviation - انحراف معیارtetrodotoxin - تترو دوتوکسین Magnetic stimulation - تحریک مغناطیسیTranscranial magnetic stimulation - تحریک مغناطیسی مغزCurrent-source density - تراکم منبع کنونیanterior auditory field - زمینه شنوایی قدامیLaminar structure - ساختار لامینارAuditory Cortex - قشر شنواییprimary auditory cortex - قشر شنوایی اولیهartificial cerebrospinal fluid - مایع مغزی نخاعی مصنوعیMicrocircuit - میکرو مدارintracortical microstimulation - میکروی تحریک داخل شکمیEEG - نوار مغزیperi-stimulus time histogram - هیستوگرام زمان پری محرکlocal field potential - پتانسیل منطقه ایGABA - گابا
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله

چکیده انگلیسی
Magnetic stimulation is widely used in neuroscience research and clinical treatment. Despite recent progress in understanding the neural modulation mechanism of conventional magnetic stimulation methods, the physiological mechanism at the cortical microcircuit level is not well understood due to the poor stimulation focality and large electric artifact in the recording. To overcome these issues, we used a sub-millimeter-sized coil (micro-coil) to stimulate the mouse auditory cortex in vivo. To determine the mechanism, we conducted the first direct electrophysiological recording of micro-coil-driven neural responses at multiple sites on the horizontal surface and laminar areas of the auditory cortex. The laminar responses of local field potentials (LFPs) to the magnetic stimulation reached layer 6, and the spatiotemporal profiles were very similar to those of the acoustic stimulation, suggesting the activation of the same cortical microcircuit. The horizontal LFP responses to the magnetic stimulation were evoked within a millimeter-wide area around the stimulation coil. The activated cortical area was dependent on the coil orientation, providing useful information on the effective position of the coil relative to the brain surface for modulating cortical circuitry activity. In addition, numerical calculation of the induced electric field in the brain revealed that the inhomogeneity of the horizontal electric field to the surface is critical for micro-coil-induced cortical activation. The results suggest that our micro-coil technique has the potential to be used as a chronic, less-invasive and highly focal neuro-stimulator, and is useful for investigating microcircuit responses to magnetic stimulation for clinical treatment.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience - Volume 371, 10 February 2018, Pages 346-370
Journal: Neuroscience - Volume 371, 10 February 2018, Pages 346-370
نویسندگان
Hisayuki Osanai, Shunsuke Minusa, Takashi Tateno,