کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8841295 | 1614711 | 2017 | 12 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Assessment of intra- and inter-regional interrelations between GABA+, Glx and BOLD during pain perception in the human brain - A combined 1H fMRS and fMRI study
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کلمات کلیدی
BOLDFWEEPItmaxGLNFWHMfMRSfunctional magnetic resonance spectroscopyMEGA-PRESSTCrMP-RAGENaAGlx - glxN-acetyl aspartate - N-استیل آسپارتاتγ-aminobutyric acid - اسید γ-آمینوبوتیریکReST - باقی ماندهecho planar imaging - تصویر برداری اکو فلاریfunctional magnetic resonance imaging - تصویرسازی تشدید مغناطیسی کارکردیfMRI - تصویرسازی تشدید مغناطیسی کارکردیfamily wise error - خطای عاقلانه خانوادهPain - دردacute pain - درد حادecho time - زمان اکوRepetition time - زمان تکرارinversion time - زمان معکوسacquisition time - زمان کسبblood oxygenation level dependent - سطح اکسیژن خون وابسته استCerebral Spinal Fluid - سیالات مغزی نخاعیCorrelation coefficient - ضریب همبستگیMR spectroscopy - طیف سنجی MRfull width at half maximum - عرض کامل در نیمی از حداکثرinsular cortex - قشر ساحلیGray matter - ماده خاکستریwhite matter - ماده سفیدCSF - مایع مغزی نخاعیREF - مرجعmagnetization prepared rapid gradient echo - مغناطیسی تهیه شده سریع اکسیژن شیبProton - پروتونtotal creatine - کل کراتینGABA - گاباGlu - گلوglutamate - گلوتاماتglutamine - گلوتامین
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
To explore brain activity and the related neurochemical processes, current research focuses increasingly on the combined acquisition of 1H MR spectra and fMRI data to investigate potential associations between local metabolite resting state levels and stimulus-induced BOLD signal changes. In this study, whole-brain fMRI measurements and localized functional 1H MEGA-PRESS MRS scans were conducted at 3T in healthy subjects prior to and during acute pain stimulation to quantify resting state GABA+/tCr and Glx/tCr levels in the insular cortex together with their stimulus-induced changes and to explore associations between these neurochemical parameters with intra-regional but also inter-regional BOLD responses. Inter-regionally, a significant negative correlation between the BOLD signal of a cluster in the supplementary motor area with overlap to the mid-cingulate cortex (Râ¯=â¯â0.56, pâ¯=â¯0.004) and the insular resting state GABA+/tCr was obtained. Furthermore, pain induced insular ÎGlx was significantly positively associated with the BOLD signal in the left superior frontal gyrus, left and right inferior frontal gyrus, left inferior parietal lobe, left superior temporal gyrus, left anterior insula and right posterior insula, with R values ranging from 0.59 to 0.73 (pâ¯<â¯0.005). No intra-regional association was observed between BOLD and metabolite measures. These findings point toward interactions between metabolite levels and stimulus-induced BOLD responses in brain regions belonging to the pain processing network. The combination of fMRS and fMRI provides a powerful tool to improve our understanding about the complex system of neurochemical processes and brain activity within brain networks.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience - Volume 365, 4 December 2017, Pages 125-136
Journal: Neuroscience - Volume 365, 4 December 2017, Pages 125-136
نویسندگان
Marianne Cleve, Alexander Gussew, Gerd Wagner, Karl-Jürgen Bär, Jürgen R. Reichenbach,