کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8841347 | 1615015 | 2018 | 15 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Ketamine modulates aggressive behavior in adult zebrafish
ترجمه فارسی عنوان
کتامین افزودن رفتار تهاجمی در پرورش ماهی قزل آلا
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کلمات کلیدی
رفتار پرخاشگرانه، داروهای روانگردانی، رفتارهای استریتیپیک، کتامین، ماهی قزل آلا،
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
چکیده انگلیسی
Ketamine is a non-competitive glutamatergic antagonist that induces analgesia and anesthesia. Although ketamine displays anxiolytic and antidepressant properties, it may induce pro-psychosis and hallucinogen effects, as well as stereotypic behaviors following acute administration at sub-anesthetic doses. Since heightened aggression is maladaptive and may comorbid with various neuropsychiatric disorders, we aimed to investigate whether ketamine modulates aggressive behavior in adult zebrafish. Fish were acutely exposed to 2, 20, and 40âmg/L ketamine for 20âmin and their locomotion, exploratory activity, and aggression towards mirror were further assessed. Ketamine (2âmg/L) increased aggression-related phenotypes, while 20 and 40âmg/L reduced aggression and elicited stereotypic behaviors by causing hyperlocomotion, altering motor patterns, and increasing circling behavior at the higher concentration tested. Collectively, our data expand the utility of zebrafish models to investigate the influence of sub-anesthetic concentrations of ketamine on aggression behavior domain in translational neuropsychiatric research field.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience Letters - Volume 684, 25 September 2018, Pages 164-168
Journal: Neuroscience Letters - Volume 684, 25 September 2018, Pages 164-168
نویسندگان
Paula Michelotti, Vanessa A. Quadros, Maria E. Pereira, Denis B. Rosemberg,