کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8841429 | 1615018 | 2018 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Treadmill exercise attenuates the severity of physical dependence, anxiety, depressive-like behavior and voluntary morphine consumption in morphine withdrawn rats receiving methadone maintenance treatment
ترجمه فارسی عنوان
ورزش تردمیل شدت وابستگی فیزیکی، اضطراب، رفتار افسردگی و مصرف مورفین داوطلبانه در موش های صحرایی مورفین را کاهش می دهد که درمان نگهدارنده متادون
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کلمات کلیدی
مورفین، ورزش، متادون، اضطراب، افسردگی، ترجیح مورفین،
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
چکیده انگلیسی
This study was designed to examine whether treadmill exercise would attenuate the severity of physical dependence, methadone-induced anxiety, depression and voluntary morphine consumption in morphine withdrawn rats receiving methadone maintenance treatment (MMT). The rats were chronically treated with bi-daily doses (10â¯mg/kg, at 12â¯h intervals) of morphine for 14â¯days. The exercising rats receiving MMT were forced to run on a motorized treadmill for 30â¯days during morphine withdrawal. Then, rats were tested for the severity of morphine dependence, the elevated plus-maze (EPM), sucrose preference test (SPT) and voluntary morphine consumption using a two-bottle choice (TBC) paradigm. The results showed that naloxone- precipitated opioid withdrawal signs were decreased in exercising morphine-dependent rats receiving MMT than sedentary rats. Also, the exercising morphine-dependent rats receiving MMT exhibited an increased time on open arms, preference for sucrose and a lower morphine preference ratio than sedentary rats. We conclude that treadmill exercise decreased the severity of physical dependence, anxiety/depressive-like behaviors and also the voluntary morphine consumption in morphine withdrawn rats receiving MMT. Thus, exercise may benefit in the treatment of addicts during MMT.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience Letters - Volume 681, 10 August 2018, Pages 73-77
Journal: Neuroscience Letters - Volume 681, 10 August 2018, Pages 73-77
نویسندگان
Maryam Alizadeh, Mahdi Zahedi-Khorasani, Hossein Miladi-Gorji,