کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8841751 1615031 2018 20 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Role of histamine H1 receptor in caffeine induced locomotor sensitization
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
Role of histamine H1 receptor in caffeine induced locomotor sensitization
چکیده انگلیسی
The present study elucidated the role of histamine H1 receptor in the caffeine induced locomotor sensitization. Intermittent administration of caffeine (15 mg/kg, i.p.) on alternate days (induction phase) i.e. 1st, 3rd, 5th, 7th, 9th, 11th and 13th resulted in the development of locomotor sensitization. In addition, challenge with sub-stimulant dose of caffeine (10 mg/kg, i.p.) directly on 17th day to induction group animals resulted in expression to locomotor sensitization to caffeine. I.c.v. injection of histaminergic agents concomitantly with caffeine during induction phase i.e. histamine H1 receptor agonist, FMPH (6.5 μg/mouse) significantly potentiated while H1 receptor antagonist, cetirizine (0.1 μg/mouse) attenuated the locomotor sensitization induced by caffeine (15 mg/kg, i.p.). In addition, challenge with caffeine (10 mg/kg, i.p.) on the expression day (17th) to the induction group mice on FMPH + caffeine treatment showed enhanced, while those on cetirizine + caffeine treatment exhibited lesser expression to locomotor sensitization. Therefore, a possible contributory role of the central histaminergic system via H1 receptor stimulation or up-regulation in the caffeine-induced locomotor sensitizing effect is proposed.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience Letters - Volume 668, 6 March 2018, Pages 60-66
نویسندگان
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