کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8841766 1615031 2018 18 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Protective effects of a radical scavenger edaravone on oligodendrocyte precursor cells against oxidative stress
ترجمه فارسی عنوان
اثرات محافظی از اداراون ردیاب رادیکال بر سلولهای پیش ساز الیگودندروستیک در برابر استرس اکسیداتیو
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب (عمومی)
چکیده انگلیسی
Oligodendrocyte precursor cells (OPCs) play critical roles in maintaining the number of oligodendrocytes in white matter. Previously, we have shown that oxidative stress dampens oligodendrocyte regeneration after white matter damage, while a clinically proven radical scavenger, edaravone, supports oligodendrocyte repopulation. However, it is not known how edaravone exerts this beneficial effect against oxidative stress. Using in vivo and in vitro experiments, we have examined whether edaravone exhibits direct OPC-protective effects. For in vivo experiments, prolonged cerebral hypoperfusion was induced by bilateral common carotid artery stenosis in mice. OPC damage was observed on day 14 after the onset of cerebral hypoperfusion, and edaravone was demonstrated to decrease OPC death in cerebral white matter. In vitro experiments also confirmed that edaravone reduced oxidative-stress-induced OPC death. Because white matter damage is a major hallmark of many neurological diseases, and OPCs are instrumental in white matter repair after injury, our current study supports the idea that radical scavengers may provide a potential therapeutic approach for white matter related diseases.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience Letters - Volume 668, 6 March 2018, Pages 120-125
نویسندگان
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