کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8841842 1615034 2018 12 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Lymphatic vasculature in human dural superior sagittal sinus: Implications for neurodegenerative proteinopathies
ترجمه فارسی عنوان
عروق لنفاوی در سینوسی ساجیتال فوق العاده انسانی: اثرات پروتئینوپاتی های عصبی
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب (عمومی)
چکیده انگلیسی
Recent reports have characterized functional lymphatic vessels, which drain both fluid and immune cells from the CSF to the deep cervical lymph nodes, lining the dural sinuses in mice. If conserved in the human brain these vessels could have profound implications for neuroinflammatory and neurodegenerative diseases. We provide evidence of the presence of lymphatic vessels in human dura obtained at autopsy, at the level of the superior sagittal sinus, in 4 individuals. Immunohistochemistry for the lymphatic vessel endothelial cell marker podoplanin revealed the widespread presence of multiple structures with a distinct lumen distributed throughout the superior sagittal sinus. These vessels provide a putative infrastructure for drainage of macromolecules from the brain parenchyma and represent an exciting avenue of exploration for involvement in the pathogenesis of neurodegenerative proteinopathies including Parkinson's disease.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience Letters - Volume 665, 5 February 2018, Pages 18-21
نویسندگان
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