کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8842066 | 1615252 | 2018 | 11 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Immediate elimination of injured white matter tissue achieves a rapid axonal growth across the severed spinal cord in adult rats
ترجمه فارسی عنوان
حذف سریع از بافت ماده سفید مصنوعی باعث افزایش رشد آکسون در ناحیه نخاعی شدید در موش صحرایی می شود
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کلمات کلیدی
PBSGFAPNFHAGCBSA - BSAbovine serum albumin - آلبومین سرم گاوImmunoreactivity - ایمنی فعالdebridement - دبریدمانCNS - دستگاه عصبی مرکزیcentral nervous system - سیستم عصبی مرکزیPhosphate buffered saline - فسفات بافر شورGray matter - ماده خاکستریwhite matter - ماده سفیدGlial fibrillary acidic protein - پروتئین اسیدی فیبریلاسیون گلایال
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
چکیده انگلیسی
In general, axonal regeneration is very limited after transection of adult rat spinal cord. We previously demonstrated that regenerative axons reached the lesion site within 6Â h of sharp transection with a thin scalpel. However, they failed to grow across the lesion site, where injured axon fragments (axon-glial complex, AGC) were accumulated. Considering a possible role of these axon fragments as physicochemical barriers, we examined the effects of prompt elimination of the barriers on axonal growth beyond the lesion site. In this study, we made additional oblique section immediately after the primary transection and surgically eliminated the AGC (debridement).ãUnder this treatment, regenerative axons successfully traversed the lesion site within 4Â h of surgery. To exclude axonal sparing, we further inserted a pored sheet into the debrided lesion and observed the presence of fascicles of unmyelinated axons traversing the sheet through the pores by electron microscopy, indicating bona fide regeneration. These results suggest that the sequential trial of reduction and early elimination of the physicochemical barriers is one of the effective approaches to induce spontaneous and rapid regeneration beyond the lesion site.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience Research - Volume 131, June 2018, Pages 19-29
Journal: Neuroscience Research - Volume 131, June 2018, Pages 19-29
نویسندگان
Takeshi Nishio, Hiroshi Fujiwara, Isaku Kanno,