کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8842122 1615256 2018 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Presynaptic active zones of mammalian neuromuscular junctions: Nanoarchitecture and selective impairments in aging
ترجمه فارسی عنوان
مناطق فعلی پیشینپتیک اتصالات عصبی-عضلانی پستانداران: نانو معماری و اختلالات انتخابی در پیری
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب (عمومی)
چکیده انگلیسی
Neurotransmitter release occurs at active zones, which are specialized regions of the presynaptic membrane. A dense collection of proteins at the active zone provides a platform for molecular interactions that promote recruitment, docking, and priming of synaptic vesicles. At mammalian neuromuscular junctions (NMJs), muscle-derived laminin β2 interacts with presynaptic voltage-gated calcium channels to organize active zones. The molecular architecture of presynaptic active zones has been revealed using super-resolution microscopy techniques that combine nanoscale resolution and multiple molecular identification. Interestingly, the active zones of adult NMJs are not stable structures and thus become impaired during aging due to the selective degeneration of specific active zone proteins. This review will discuss recent progress in the understanding of active zone nanoarchitecture and the mechanisms underlying active zone organization in mammalian NMJs. Furthermore, we will summarize the age-related degeneration of active zones at NMJs, and the role of exercise in maintaining active zones.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience Research - Volume 127, February 2018, Pages 78-88
نویسندگان
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