کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8842161 | 1615259 | 2017 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Visual discrimination and reversal learning in aged common marmosets (Callithrix jacchus)
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
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چکیده انگلیسی
Common marmosets (Callithrix jacchus) have been suggested as a new model for analysis of age-related changes and neurodegenerative diseases. However, the effects of age on learning and memory processes are not well defined within this species. Therefore, we employed visual discrimination and reversal learning tasks to evaluate learning and memory in four aged common marmosets relative to a younger cohort. We found that aged marmosets commit significantly more errors in initial stages of visual discrimination and more perseverative errors in reversal learning, indicating prefrontal dysfunction. However, they showed comparable performance with younger marmosets in the later stages of both tasks.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience Research - Volume 124, November 2017, Pages 57-62
Journal: Neuroscience Research - Volume 124, November 2017, Pages 57-62
نویسندگان
Emily L. Munger, Atsushi Takemoto, Mary Ann Raghanti, Katsuki Nakamura,