کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8842446 1615544 2017 42 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Efferent modulation of pre-neural and neural distortion products
ترجمه فارسی عنوان
مدولاسیون افراطنت از محصولات پیشگیرنده عصبی و عصبی مصنوعی
کلمات کلیدی
انتشارات اتوآکوستیک محصول تحریف شده، پاسخ فرکانسی زیر، رفلکس عصبی مرکزی، اثیری
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی سیستم های حسی
چکیده انگلیسی
Distortion product otoacoustic emissions (DPOAEs) and distortion product frequency following responses (DPFFRs) are respectively pre-neural and neural measurements associated with cochlear nonlinearity. Because cochlear nonlinearity is putatively linked to outer hair cell electromotility, DPOAEs and DPFFRs may provide complementary measurements of the human medial olivocochlear (MOC) reflex, which directly modulates outer hair cell function. In this study, we first quantified MOC reflex-induced DPOAE inhibition at spectral fine structure peaks in 22 young human adults with normal hearing. The f1 and f2 tone pairs producing the largest DPOAE fine structure peak for each subject were then used to evoke DPFFRs with and without MOC reflex activation to provide a related neural measure of efferent inhibition. We observed significant positive relationships between DPOAE fine structure peak inhibition and inhibition of DPFFR components representing neural phase locking to f2 and 2f1-f2, but not f1. These findings may support previous observations that the MOC reflex inhibits DPOAE sources differentially. That these effects are maintained and represented in the auditory brainstem suggests that the MOC reflex may exert a potent influence on subsequent subcortical neural representation of sound.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Hearing Research - Volume 356, December 2017, Pages 25-34
نویسندگان
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