کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8853059 1618900 2018 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Transcriptome analysis of the effects of Cd and nanomaterial-loaded Cd on the liver in zebrafish
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم محیط زیست شیمی زیست محیطی
پیش نمایش صفحه اول مقاله
Transcriptome analysis of the effects of Cd and nanomaterial-loaded Cd on the liver in zebrafish
چکیده انگلیسی
The wide application of engineered nanoparticles to remove heavy metals in aquatic environments has raised concerns over nanomaterial-adsorbed heavy metal toxicity. To ensure safe use of nanomaterial-heavy metal composites, understanding their biological effects at the molecular level is crucial. In the present study, we used the Illumina HiSeq technology to study the transcriptome changes induced by Cd2+ and nano-manganese dioxide- or nano-hydroxyapatite-adsorbed CdCl2 composites (nMnO2-Cd, nHAP20-Cd, and nHAP40-Cd) in zebrafish liver cells. We identified 545 differentially expressed genes (DEGs), 33 of which were in common between the nMnO2-Cd, nHAP20-Cd, and nHAP40-Cd groups. The DEGs could be classified in four categories: hydrolases (enzymes involved in various physiological functions, including digestion, immune response, blood coagulation, and reproduction), biological binding (FMN-, actin- and metal ion-binding), metabolic enzymes (e.g., ceramidase, alpha-amylase, carboxylic ester hydrolase, and carboxypeptidase), and cell structure (cell surface, intermediate filament, and muscle myopen protein). The DEGs identified in this study are potentially useful markers to understand the physiological responses induced by Cd2+ and nano-Cd composites in zebrafish liver.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Ecotoxicology and Environmental Safety - Volume 164, 30 November 2018, Pages 530-539
نویسندگان
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