کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8853567 1618905 2018 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Quantitative ecotoxicity analysis for pesticide mixtures using benchmark dose methodology
ترجمه فارسی عنوان
تجزیه و تحلیل کمی اکسی توسین برای مخلوط آفت کش ها با استفاده از روش دوز معیار
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم محیط زیست شیمی زیست محیطی
چکیده انگلیسی
The objective of this study is to quantify the ecotoxicity of pesticide mixtures composed of different combinations of four pesticides (i.e., Acetemiprid, Carbendazim, Chlorpyrifos, Cyhalothrin) to (1) understand if the co-presence of multiple pesticides will affect the toxicity and (2) to quantitatively approximate the change in toxicity. We first conducted acute toxicity testing and avoidance response testing using earthworms to obtain dose-response data for two different endpoints; then the benchmark dose (BMD) methodology was applied to estimate the toxicity values for the active ingredients of these four pesticides and their mixtures. The BMD analysis results suggest that the ecotoxicity of the active ingredients of the pesticides is very likely to increase when two or more pesticides are used simultaneously, highlighting the importance to consider toxicity of mixtures in the regulatory decision making process. This study demonstrates that the benchmark dose methodology can be a useful tool to quantify the toxicity of chemical mixtures and support cumulative risk assessment accordingly.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Ecotoxicology and Environmental Safety - Volume 159, 15 September 2018, Pages 94-101
نویسندگان
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