کد مقاله کد نشریه سال انتشار مقاله انگلیسی ترجمه فارسی نسخه تمام متن
8853726 1618906 2018 7 صفحه PDF سفارش دهید دانلود رایگان
عنوان انگلیسی مقاله ISI
Internal concentrations of perfluorobutane sulfonate (PFBS) comparable to those of perfluorooctane sulfonate (PFOS) induce reproductive toxicity in Caenorhabditis elegans
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
سفارش ترجمه تخصصی
با تضمین قیمت و کیفیت
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم محیط زیست شیمی زیست محیطی
پیش نمایش صفحه اول مقاله
Internal concentrations of perfluorobutane sulfonate (PFBS) comparable to those of perfluorooctane sulfonate (PFOS) induce reproductive toxicity in Caenorhabditis elegans
چکیده انگلیسی
Perfluorobutane sulfonate (PFBS) is considered a less-toxic replacement for perfluorooctane sulfonate (PFOS), with multiple applications in industrial and consumer products. Previous studies comparing their toxicity generally used similar exposure levels, without taking internal concentrations into account. The current study compared the reproductive toxicity of PFOS and PFBS, at similar internal concentrations, to Caenorhabditis elegans (C. elegans). PFBS was much less bioaccumulative than PFOS. The 48-h median lethal concentrations (LC50) for PFOS and PFBS were 1.4 μM (95% confidence interval [CI]: 1.1-1.6) and 794 μM (95% CI: 624-1009), respectively. Egg production and brood number of C. elegans decreased markedly following exposure to 0.1 μM PFOS or 1000 or 1500 μM PFBS. Germ-cell apoptosis and production of reactive oxygen species increased significantly following exposure to 2 μM PFOS or 500 or 1000 μM PFBS. Expression of the antioxidant genes sod-3, ctl-2, and gst-4 and the pro-apoptotic genes egl-1 and ced-13 was altered significantly following PFOS and PFBS exposure. These findings indicate that both chemicals exert reproductive toxicity in C. elegans, probably owing to germ-cell apoptosis resulting from elevated levels of reactive oxygen species. The vastly different exposure concentrations of PFBS and PFOS used in this study produced similar internal concentrations, leading to the reproductive toxicities observed.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Ecotoxicology and Environmental Safety - Volume 158, 30 August 2018, Pages 223-229
نویسندگان
, , , , , , , ,
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
سفارش ترجمه تخصصی
با تضمین قیمت و کیفیت