کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8875409 | 1623655 | 2016 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Ameliorative effects of Musa sapientum peel extract on acetic acid-induced colitis in rats
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
علوم کشاورزی و بیولوژیک (عمومی)
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چکیده انگلیسی
Ameliorative effects of Musa sapientum peel extract (MSPE) were studied on Acetic Acid (AA)-induced colitis in rats. From a dose response study, the effective and yet, safe for the treatment of AA-induced colitis in rats was determined, and also, a further study was carried out to determine the effective fraction(s) of MSPE that will be useful in the treatment of AA induced colitis in rats. Colitis was induced with 0.2Â ml of 6% acetic acid through a lower abdominal laparotomy. Treatment with graded doses of methanolic extract of dried peel of Musa sapientum (MS) (50, 100 and 200Â mg/kg) for 7Â days in AA induced colitis in rats showed 50Â mg/kg as an optimal effective dose for the healing of AA induced colitis in rats. This dose (50Â mg/kg) was further studied with fractions of MSPE in comparison to a standard drug (sulfasalazine) of the same dose (50Â mg/kg) on AA induced colitis in rats for 18Â days. Colitis was assessed using stool consistency, macroscopic gross score and histological studies. Normal stool consistency was seen early in treated animals as compared with control; MS peel (crude extracts and fractions) significantly reduced macroscopic and histologic colon tissue damage in a manner similar to that of sulfasalazine. The results from these findings suggests that MSPE fractions of ethyl acetate and methanol may be effective in reducing both macroscopic and histological damage in a manner similar to sulfasalazine, and that it may be helpful in the treatment of colitis.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: The Journal of Basic & Applied Zoology - Volume 77, October 2016, Pages 49-55
Journal: The Journal of Basic & Applied Zoology - Volume 77, October 2016, Pages 49-55
نویسندگان
Gbemisola A. Adegoke, Samuel A. Onasanwo, O. David Eyarefe, Samuel B. Olaleye,