کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8883762 | 1625906 | 2018 | 38 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Toxicokinetic and toxicodynamic studies of carbaryl alone or in binary mixtures with azinphos methyl in the freshwater gastropod Planorbarius corneus
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کلمات کلیدی
p-NPBp-NPACyPB-esterasesBCFAcSChCarboxylesterasesDTNBCPFAZMPlanorbarius corneusMixtures - مخلوط هاOPs - OP هاp-nitrophenyl butyrate - p-nitrofenyl butyratep-Nitrophenyl acetate - p-نیترفنیل استاتAChE - آهیAzinphos-methyl - آینفوس متیلAcetylthiocholine iodide - اتیل تیوکولین یدیدOrganophosphates - ارگانوفسفاتAcetylcholinesterase - استیل کولین استرازCES - اینToxicokinetics - تاکسیکوسینتیک، تاکسیکوکینتیکCytochrome P450 - سیتوکروم پی۴۵۰bioconcentration factor - فاکتور زیستی کنسانترهCarbaryl - کاربیریلChlorpyrifos - کلرپیریفوسCHE - کهCholinesterase - کولین استراز
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
علوم آبزیان
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Toxicokinetic and toxicodynamic studies of carbaryl alone or in binary mixtures with azinphos methyl in the freshwater gastropod Planorbarius corneus Toxicokinetic and toxicodynamic studies of carbaryl alone or in binary mixtures with azinphos methyl in the freshwater gastropod Planorbarius corneus](/preview/png/8883762.png)
چکیده انگلیسی
Carbamate insecticides such as carbaryl and organophosphates such as azinphos-methyl share the ability to inhibit the activity of B-esterases. This study aimed to (1) assess the inhibitory effects of carbaryl on B-esterase activity in soft tissues and hemolymph of Planorbarius corneus; (2) establish whether binary mixtures of carbaryl and azinphos-methyl depart or not from a model of concentration addition on the inhibition of cholinesterase activity; (3) determine the bioconcentration and elimination of the pesticides. The results showed that exposure of gastropods to increasing concentrations of carbaryl (0.1-5â¯mgâ¯Lâ1) for 48â¯h inhibited cholinesterase activity in a concentration-dependent manner, with an EC50 of 1.4â¯Â±â¯0.3â¯mgâ¯Lâ1 and 1.2â¯Â±â¯0.1â¯mgâ¯Lâ1 for soft tissue and hemolymph, respectively. Carboxylesterase activity, measured with the substrates p-nitrophenyl butyrate and p-nitrophenyl acetate, was between 2.3 and 25 times more sensitive to carbaryl inhibition than cholinesterase activity. Binary mixtures corresponding to 0.5 EC50 carbarylâ¯+â¯0.5 EC50 azinphos-methyl and 0.75 EC50 carbarylâ¯+â¯0.75 EC50 azinphos-methyl produced inhibitions of cholinesterase activity similar to those of individual pesticides, following a model of concentration addition. Bioconcentration was analyzed using a one-compartment model. The absorption kinetics (k1) for both pesticides alone (1.4â¯mgâ¯Lâ1 of carbaryl or 1.8â¯mgâ¯Lâ1 of azinphos-methyl) or mixed (1.4â¯mgâ¯Lâ1 of carbarylâ¯+â¯1.8â¯mgâ¯Lâ1 of azinphos-methyl) were similar. The elimination kinetics ratio (k2) estimated for the pesticides alone or in the mixtures showed that carbaryl was eliminated 3.5 times faster than azinphos-methyl. These results suggest that exposure of Planorbarius corneus to binary mixtures of carbaryl and azinphos-methyl for 48â¯h follow a concentration addition model on inhibition of cholinesterase activity and that the pesticide mixtures do not change the toxicokinetic parameters of the parent compounds.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Aquatic Toxicology - Volume 199, June 2018, Pages 276-284
Journal: Aquatic Toxicology - Volume 199, June 2018, Pages 276-284
نویسندگان
Luis Claudio Cacciatore, Noemà Rosario Verrengia Guerrero, Adriana Cristina Cochón,