کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8884184 | 1626292 | 2018 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Organic osmolytes of amphipods from littoral to hadal zones: Increases with depth in trimethylamine N-oxide, scyllo-inositol and other potential pressure counteractants
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
علوم زمین و سیارات
زمین شناسی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Organic osmolytes of amphipods from littoral to hadal zones: Increases with depth in trimethylamine N-oxide, scyllo-inositol and other potential pressure counteractants Organic osmolytes of amphipods from littoral to hadal zones: Increases with depth in trimethylamine N-oxide, scyllo-inositol and other potential pressure counteractants](/preview/png/8884184.png)
چکیده انگلیسی
Deep-sea organisms must cope with hydrostatic pressure, up to ~ 110â¯MPa (~ 1100â¯atm) at 11â¯km in the Mariana Trench. Pressure perturbs protein conformations, ligand binding, and can promote damaging protein aggregates. Salinity is another stressor: seawater, averaging ~ 1000 mOsm/kg, is dehydrating towards the ~ 250-400 mOsm/kg of universal cellular solutes. Most marine organisms prevent dehydration by becoming isosmotic with cellular organic osmolytes, which, unlike NaCl, do not perturb proteins and can have chemical chaperone properties, stabilizing proteins against various physicochemical stressors. In shallow-dwelling invertebrates, these osmolytes are typically taurine, glycine, and betaine. Previous work on crustaceans down to 3â¯km found that “shallow” osmolytes decreased with depth, replaced with trimethylamine N-oxide (TMAO) and other apparent chemical chaperones. In bony fishes, TMAO increases with depth down to 8â¯km, and is probably a piezolyte (pressure counteractant) as it reverses pressure's inhibitory effects. Here we analyzed amphipods over the full ocean depth range of 0-11â¯km, from coastal habitats and numerous depths in the Kermadec and Mariana Trenches. We found that “shallow” osmolytes decreased while potential piezolytes, in different combinations in different species, increased with depth. These are TMAO, glycerophosphorylcholine and proline betaine (all methylamine chaperones), glycerophosphorylethanolamine, and scyllo-inositol, a polyol chaperone (being tested for Alzheimer's Disease) that works differently than methylamines by preventing damaging protein aggregations. Though only TMAO has been tested for piezolyte properties, these other solutes may explain how some hadal amphipods live deeper than fish, which appear to be limited to a maximum of 8.4â¯km.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Deep Sea Research Part I: Oceanographic Research Papers - Volume 138, August 2018, Pages 1-10
Journal: Deep Sea Research Part I: Oceanographic Research Papers - Volume 138, August 2018, Pages 1-10
نویسندگان
Anna B. Downing, Gemma T. Wallace, Paul H. Yancey,