The role of LpxA/C/D and pmrA/B gene systems in colistin-resistant clinical strains of Acinetobacter baumannii

Mechanisms of colistin resistance in clinical strains of A. baumannii show that colistin may not serve as an antibiotic of the last resort for treating MDR A. baumannii infections when other antibiotics are ineffective. The mechanisms of colistin resistance should provide an impetus for future research on the development of newer alternative therapies to treat emerging MDR A. baumannii.