کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8921832 | 1643389 | 2017 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Extracellular matrix in mammary gland development and breast cancer progression
ترجمه فارسی عنوان
ماتریکس خارج سلول در توسعه ژن پستان و پیشرفت سرطان پستان
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
بیوتکنولوژی یا زیستفناوری
چکیده انگلیسی
Extracellular matrix (ECM) is one of the essential components of the tumor microenvironment. Increased ECM deposition has been detected in many types of solid tumors including breast cancer, in which the development and progression require extensive reorganization of ECM. The chemical and physical signals induced by ECM are necessary for breast cancer development and progression. Disturbing the fine balance of ECM signaling is very important in the long run to promote breast cancer development and progression. In this review, we summarized recent findings on functions of ECM microenvironment in mammary gland development, tumor growth, invasion, migration and metastasis, focusing on the functions of cancer cell-derived ECM in tumor progression. Our review showed that integrated biophysical and biochemical signals from ECM and soluble factors are crucial for normal mammary gland development and breast cancer progression.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Frontiers in Laboratory Medicine - Volume 1, Issue 1, March 2017, Pages 36-39
Journal: Frontiers in Laboratory Medicine - Volume 1, Issue 1, March 2017, Pages 36-39
نویسندگان
Gaofeng Hu, Linzhang Li, Wei Xu,