Nitrogen-containing bisphosphonates for burn-related heterotopic ossification

Nitrogen-containing bisphosphonates may have an adjunctive role in the surgical treatment of burn-related HO. Specifically, they may be useful for hastening maturity of burn-related HO. It is not known if peri-operative dosing may be useful around the time of surgical resection. These drugs have been used in the ICU, acute care, and outpatient settings at a tertiary burn center without complications.