Desflurane but not sevoflurane can increase lung resistance via tachykinin pathwaysâ€

Desflurane but not sevoflurane increased RL concomitant with a decrease in CDyn in guinea pigs. The increase in lung resistance by desflurane might be due to antidromic tachykinin release from afferent C-fibres but not acetylcholine release from parasympathetic efferent nerves.