Comparison of the effects of intrathecal administration of levobupivacaine and lidocaine on the prostaglandin E2 and glutamate increases in cerebrospinal fluid: a microdialysis study in freely moving rats

Spinal PGE2 levels are similarly increased after i.t. levobupivacaine injection of 250 and 100 μg. A higher PGE2 response was observed after a second i.t. injection in the animals receiving 1000 μg lidocaine than those receiving 400 mg lidocaine or either dose of levobupivacaine.