Multi-level approach to anaesthetic effects produced by sevoflurane or propofol in humans: 1. BIS and blink reflexâ€

The blink reflex (brainstem function) is more sensitive to sevoflurane or propofol than BIS (forebrain function). Sevoflurane suppresses the blink reflex more than propofol. Different ke0s for blink reflex vs BIS indicate different effect sites.