Predictive performance of 'Servin's formula' during BIS®-guided propofol-remifentanil target-controlled infusion in morbidly obese patients

Significant bias between predicted and measured plasma propofol concentrations was found while the low wobble values suggest that propofol TCI system is able to maintain stable drug concentrations over time. As already suggested before, a computer simulation confirmed that the TCI system performance could be significantly improved when total body weight is used.