کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8943436 1645145 2018 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Controlled engineering of highly aligned fibrous dosage form matrices for controlled release
ترجمه فارسی عنوان
مهندسی کنترل شده از ماتریس های فرمولاسیون فیبر دار برای کنترل آزاد شده بسیار خطی است
موضوعات مرتبط
مهندسی و علوم پایه مهندسی مواد فناوری نانو (نانو تکنولوژی)
چکیده انگلیسی
In this study, complex drug-cellulose acetate (CA) composite films were designed and fabricated possessing pre-determined grid spacing for inter-connected fibrous films. Ibuprofen (IBU) was selected as the active ingredient and grid spacing was varied between 300 and 500 μm (fiber diameter ∼ 35 μm) for various geometries. Process parameter impact on fiber morphology and deposition was investigated. FTIR confirmed IBU encapsulation and XRD analysis indicated the drug was dispersed (amorphous) in films. Inter-connected grid void geometry was shown to impact water contact behavior, and drug release mechanism was shown to be Fickian diffusion. Furthermore, drug release rate depended on geometry of engineered structures. The findings suggest a spatial design approach for modulated drug release from bespoke drug delivery dosage forms.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Materials Letters - Volume 232, 1 December 2018, Pages 134-137
نویسندگان
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