Antibacterial activity of decahedral cinnamon nanoparticles prepared in honey using PLAL technique

Presence of rich bioactive compounds (polyphenol, cinnamaldehyde and flavanols) in cinnamon make them greatly beneficial for biomedicinal and food applications. Considering such prospects, we prepared decahedral cinnamon nanoparticles (DCNPs) in pure honey via pulse laser ablation in liquid (PLAL) technique at varied laser ablation energy (LAE, 0-180 mJ) and characterized. LAE dependent structure and morphology of such DCNPs were determined. DCNPs grown at LAE of 90 mJ manifested the best size distribution with average diameter of 17.08 ± 4.71 nm. Furthermore, bactericidal traits of these DCNPs against Escherichia coli (EC) and Bacillus subtilis (BS) bacterial strains were assessed using agar well diffusion and optical density analyses. The DCNPs assisted inhibition zone diameter-antibiotic tested against such bacterial strains was remarkably enlarged. The proposed DCNPs were shown to be effective for the development of future nanomedicine.