کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8943508 1645149 2018 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Spontaneous mutation rate as a source of diversity for improving desirable traits in cultured microalgae
ترجمه فارسی عنوان
نرخ جهش خود به خودی به عنوان منبع تنوع برای بهبود صفات مطلوب در میکروالگوهای کشت شده
موضوعات مرتبط
مهندسی و علوم پایه مهندسی انرژی انرژی های تجدید پذیر، توسعه پایدار و محیط زیست
چکیده انگلیسی
Mutations are the main origin of the biodiversity and biological innovations across the tree of life. The number of mutations in a population depends of the mutation rate, noted μ, a key parameter for understanding the evolutionary and adaptive capacity of a species. New mutations are submitted to selection and drift and their probability of fixation in a population depends on their advantageous, deleterious or neutral fitness effect. This process occurs in natural populations, but also in any lab cultures. In this context, the role of spontaneous mutations in the generation of genetic diversity in cultured algae has so far been overlooked, despite its influence on the acquisition and maintenance of desirable phenotypic traits. Several algal species that have a high biotechnological potential, such those producing high-value molecules, might be improved by domestication and oriented selection by experimental evolution. Here, we provide the first estimation of the spontaneous mutation rate, μ, in Picochlorum costavermella (Trebouxiophyceae), a green alga with many potential biotechnological applications. Its spontaneous mutation rate is μ = 10.12 × 10−10 (CI Poisson distribution, μ = 6.3-15.4 × 10−10) mutations per nucleotide per genome per generation. This is one of the highest mutation rates reported for a unicellular eukaryote.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Algal Research - Volume 35, November 2018, Pages 85-90
نویسندگان
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