کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8943693 1645202 2018 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Role of activating transcription factor 3 and its interacting proteins under physiological and pathological conditions
ترجمه فارسی عنوان
نقش فاکتور رونویسی فعال 3 و پروتئین های تعامل کننده آن در شرایط فیزیولوژیکی و پاتولوژیک
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
چکیده انگلیسی
Activating transcription factor 3 (ATF3) is a stress-responsive factor that belongs to the activator protein 1 (AP-1) family of transcription factors. ATF3 expression is stimulated by various factors such as hypoxia, cytokines, and chemotherapeutic and DNA damaging agents. Upon stimulation, ATF3 can form homodimers or heterodimers with other members of the AP-1 family to repress or activate transcription. Under physiological conditions, ATF3 expression is transient and plays a pivotal role in controlling the expression of cell-cycle regulators and tumor suppressor, DNA repair, and apoptosis genes. However, under pathological conditions such as those during breast cancer, a sustained and prolonged expression of ATF3 has been observed. In this review, the structure and function of ATF3, its posttranslational modifications (PTM), and its interacting proteins are discussed with a special emphasis on breast cancer metastasis.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Biological Macromolecules - Volume 120, Part A, December 2018, Pages 310-317
نویسندگان
, , ,