کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8943826 | 1645208 | 2018 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Equine chorionic gonadotrophin improved vascularization of feline ovarian tissue xenografted into immunosuppressed mice
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موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
علوم دامی و جانورشناسی
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چکیده انگلیسی
The objective of this study was to evaluate effects of eCG on vascularization and development of feline ovarian tissue xenografted to immunosuppressed mice. Feline ovarian fragments (â¼1â¯mm3) were transplanted under the renal capsule of 20 adult, ovariectomized, C57BL/6 SCID female mice. At 45â¯d after transplantation, 10 mice (controls) were euthanized and the remainder given 10 IU of eCG (and sacrificed 48â¯h later). Transplants were recovered immediately after death, fixed, sectioned, and stained with periodic acid-Schiff (PAS). Fragment volume (Cavallieri principle) and vascularization were assessed. Mean xenotransplant volume for control and treatment groups was 0.17â¯Â±â¯0.03 and 0.37â¯Â±â¯0.13â¯mm3, respectively (Pâ¯=â¯0.0952); vascular volume density, 30.3â¯Â±â¯11.3 and 49.1â¯Â±â¯8.9% (Pâ¯=â¯0.0281); surface density, 4.1â¯Â±â¯2.4 and 6.2â¯Â±â¯1.7â¯Î¼mâ1â¯(Pâ¯=â¯0.2222); and vessel total surface, 0.63â¯Â±â¯0.24â¯Î¼m2 and 2.28â¯Â±â¯1.05â¯Î¼m2â¯(Pâ¯=â¯0.0079). In conclusion, eCG significantly increased vascular volume density of xenotransplanted ovarian tissue and improved its development.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Theriogenology - Volume 121, November 2018, Pages 78-81
Journal: Theriogenology - Volume 121, November 2018, Pages 78-81
نویسندگان
Luã Barbalho de Macêdo, Muriel Magda Lustosa Pimentel, Fernanda Araujo dos Santos, Marcelo Barbosa Bezerra, Fernando Vagner Lobo Ladd, Carlos Eduardo Bezerra de Moura,