کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8943870 | 1645212 | 2018 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Muscularis macrophages: Key players in intestinal homeostasis and disease
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کلمات کلیدی
α7nAChRPOIVNSCAIPβ2-ARENSDCsICCI/R - I / RMϕ - Mφα7 Nicotinic receptor - α7 گیرنده نیکوتینGastrointestinal disorders - اختلالات دستگاه گوارشischemia-reperfusion - ایسکمی-رپرفیوژنvagus nerve stimulation - تحریک عصب واگneuro-immune interactions - تعاملات ایمنی عصبیCNS - دستگاه عصبی مرکزیDendritic cells - سلول های دندریتیکinterstitial cells of Cajal - سلولهای بینابینی Cajalenteric nervous system - سیستم عصبی روده ایcentral nervous system - سیستم عصبی مرکزیMacrophage - ماکروفاژ Cholinergic anti-inflammatory pathway - مسیر ضد التهابی روده ای کلینرژیکPostoperative ileus - یبوست بعد از عمل
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
بیولوژی سلول
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Macrophages residing in the muscularis externa of the gastrointestinal tract are highly specialized cells that are essential for tissue homeostasis during steady-state conditions as well as during disease. They are characterized by their unique protective functional phenotype that is undoubtedly a consequence of the reciprocal interaction with their environment, including the enteric nervous system. This muscularis macrophage-neuron interaction dictates intestinal motility and promotes tissue-protection during injury and infection, but can also contribute to tissue damage in gastrointestinal disorders such as post-operative ileus and gastroparesis. Although the importance of muscularis macrophages is clearly recognized, different aspects of these cells remain largely unexplored such their origin, longevity and instructive signals that determine their function and phenotype. In this review, we will discuss the phenotype, functions and origin of muscularis macrophages during steady-state and disease conditions. We will highlight the bidirectional crosstalk with neurons and potential therapeutic strategies that target and manipulate muscularis macrophages to restore their protective signature as a treatment for disease.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cellular Immunology - Volume 330, August 2018, Pages 142-150
Journal: Cellular Immunology - Volume 330, August 2018, Pages 142-150
نویسندگان
Sebastiaan De Schepper, Nathalie Stakenborg, Gianluca Matteoli, Simon Verheijden, Guy E. Boeckxstaens,