Polyostéopathie hypertrophiante (syndrome de Cadiot-Ball) secondaire à un carcinome transitionnel urétral métastasé au poumon chez une chienne Border Collie de 9 ans

Hypertrophic osteopathy (Cadiot-Ball syndrome) is a rare condition involving a diaphyseal osteoperiosteal reaction of the long bones, most often of paraneoplastic origin, associated with primitive tumors of the lung or with pulmonary metastasis. A female Border Collie dog is referred for consultation for deformation of the four limbs associated with chronic hyperthermia over the course of one month and dysuria. Biochemical and hematological profiles did not reveal a major anomaly. The clinical exam reveals hyperthermia and bone deformation in the distal region of the femoral and humeral diaphyses and in the proximal region of the tibio-fibular and radio-ulnar diaphyses. Bladder distension and severe dysuria are also noted. The principal hypothesis is of a hypertrophic polyosteopathy. X-rays of the limbs highlight significant osteoproliferation of nearly all the osseous shafts. A thoracic X-ray shows several pulmonary masses. A vesical catheter allows a proximal urethral obstruction to be observed. Abdominal ultrasound reveals vesical distension as well as numerous masses in the trigonal region. Cytological analysis indicates transitional cell carcinoma of the epithelium. This case illustrates that the clinical manifestations of Cadiot-Ball syndrome generally appear before initial cancer symptoms, even when the cancer has already spread significantly.