کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8944375 1645245 2018 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Sacubitril/valsartan: A novel angiotensin receptor-neprilysin inhibitor
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی کاردیولوژی و پزشکی قلب و عروق
پیش نمایش صفحه اول مقاله
Sacubitril/valsartan: A novel angiotensin receptor-neprilysin inhibitor
چکیده انگلیسی
Effective reduction of blood pressure to accepted goals is the key to reduce the risk of CV events and stroke. Dual inhibition of neprilysin and the angiotensin receptor with sacubitril/valsartan may represent an attractive and serendipitous therapeutic approach for a range of CV diseases, including hypertension and HF, in which vasoconstriction, volume overload and neuro-hormonal activation play a part in pathophysiology. Sacubitril/Valsartan appears to be more efficacious in reducing blood pressure than currently available ACEi and ARBs with a similar safety and tolerability profile. Besides, pleiotropic benefits like HbA1c reduction, better eGFR progression and a greater decrease in blood pressure and serum creatinine levels make this drug a novel addition to the current hypertension armamentarium.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Indian Heart Journal - Volume 70, Supplement 1, July 2018, Pages S102-S110
نویسندگان
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