Determining the Role and Duration of the “Antibiotic Holiday” Period in Periprosthetic Joint Infection

The duration of an antibiotic-free period does not appear to significantly affect PJI rate after reimplantation. However, many patients fail during the antibiotic-free period. Further prospective studies are needed to determine the optimal timing of reimplantation for 2-stage exchange arthroplasty for PJI treatment.