کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8952337 | 1645858 | 2018 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Atypical Presentation of Pregnancy-Related Hemolytic Uremic Syndrome
ترجمه فارسی عنوان
معرفی غیرمعمول سندرم حاملگی همولیتیک اورمیک
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کلمات کلیدی
acute kidney injury (AKI) - آسیب حاد کلیه (AKI)Eclampsia - اکلامپسیPregnancy - بارداریKidney biopsy - بیوپسی کلیهDifferential diagnosis - تشخیص های افتراقیPostpartum period - دوره پس از زایمانHemolytic uremic syndrome (HUS) - سندروم اورلیمی همولیتیک (HUS)Thrombotic microangiopathy (TMA) - میکروآنژیوپاتی ترومبوتیک (TMA)pre-eclampsia - پره اکلامپسی
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
بیماریهای کلیوی
چکیده انگلیسی
The cause of acute kidney injury during pregnancy and in the postpartum period can be particularly challenging to diagnose, especially when it is necessary to differentiate among preeclampsia; eclampsia; hemolysis, elevated liver enzymes and low platelets (HELLP) syndrome; and thrombotic microangiopathies (TMAs). All these disease entities can present with kidney failure, microangiopathic hemolytic anemia, and thrombocytopenia. We present a teaching case of atypical hemolytic uremic syndrome in the postpartum period in a young woman who was found to have mutations of uncertain clinical significance in the complement cascade, including in C3, CFH, and CFI. We use this as an opportunity to review the clinical presentation and pathophysiology of preeclampsia, eclampsia, and the TMAs. We focus on diagnostic challenges, especially because many patients with TMA do not present with thrombocytopenia, which can delay diagnosis. We additionally review the clinical settings in which administration of eculizumab, a C5 membrane attack complex inhibitor, is appropriate.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: American Journal of Kidney Diseases - Volume 72, Issue 3, September 2018, Pages 451-456
Journal: American Journal of Kidney Diseases - Volume 72, Issue 3, September 2018, Pages 451-456
نویسندگان
Salim Baghli, Catherine Abendroth, Umar Farooq, Jennifer A. Schaub,