کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8963432 | 1646619 | 2018 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Homing of the Stem Cells from the Acupoint ST-36 to the Site of a Spinal Cord Injury: A Preliminary Study
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
طب مکمل و جایگزین
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Homing of stem cells (SCs) to desired targets such as injured tissues remains a lingering problem in cell-based therapeutics. Studies on the biodistribution of intravenously administered SCs have shown the inefficacy of blood vessels as the homing path because most of the injected SCs are captured in the capillary beds of the lungs. We considered an alternative administration method using the acupuncture meridians or the primo vascular system. We injected SCs at the acupoint Zusanli (ST-36) below the knee of a nude mouse with a spinal cord injured at the thoracic T9-10 vertebrae. The SCs migrated from the ST-36, along the sciatic nerve, the lumbar 4-5, and then the spinal cord to the injury point T9-10. The SCs were not randomly scattered but were rather well aligned like marathon race runners, along the primo vascular system route toward the injury point. We observed the SCs at 1, 3, 6, 9, 12, and 15Â hours after injection. The fast runners among the injected SCs took about 6Â hours to reach the sciatic nerve, about 9Â hours to reach the lumbar 4-5, and about 15Â hours to reach the injury point T9-10.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Acupuncture and Meridian Studies - Volume 11, Issue 4, August 2018, Pages 133-136
Journal: Journal of Acupuncture and Meridian Studies - Volume 11, Issue 4, August 2018, Pages 133-136
نویسندگان
Sharon Jiyoon Jung, Myung Geun Kook, Sungchul Kim, Kyung-Sun Kang, Kwang-Sup Soh,